ITN2135
ITN2135
- Catalog: ITN2135
- Gene/Protein: PARP10
- Product Description: Immunotag™ PAR10 Polyclonal Antibody
385.0000
Price in reward points: 385
Your shopping cart is empty!
Antibody Specification | |
Datasheet | |
Target Protein | PAR10 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | PAR10 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | PARP10 |
Accession No. | Q53GL7 |
Description | poly(ADP-ribose) polymerase family member 10(PARP10) Homo sapiens Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008], |
Protein Expression | Kidney,Mammary gland,Skin,Thyroid,Uterus, |
Subcellular Localization | nucleus,nucleoplasm,nucleolus,cytoplasm,Golgi apparatus, |
Protein Function | catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.,PTM:Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.,similarity:Contains 1 PARP catalytic domain.,subcellular location:Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase.,subunit:Interacts with MYC.,tissue specificity:Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |