ITN2137
ITN2137
- Catalog: ITN2137
- Gene/Protein: MMEL1 MELL1 MMEL2 NEP2
- Product Description: Immunotag™ MMEL1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | MMEL1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MMEL1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | MMEL1 MELL1 MMEL2 NEP2 |
| Accession No. | Q495T6 Q9JLI3 P0C1T0 |
| Description | membrane metalloendopeptidase like 1(MMEL1) Homo sapiens The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008], |
| Protein Expression | Testis, |
| Subcellular Localization | extracellular region,integral component of membrane, |
| Protein Function | catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by thiorphan and phosphoramidon.,function:Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M13 family.,subcellular location:A secreted form produced by proteollytic cleavage also exists.,tissue specificity:Predominantly expressed in testis. Weakly expressed in brain, kidney and heart., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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