ITN2154
ITN2154
- Catalog: ITN2154
- Gene/Protein: ERAP2 LRAP
- Product Description: Immunotag™ ERAP2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ERAP2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | ERAP2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ERAP2 LRAP |
| Accession No. | Q6P179 |
| Description | endoplasmic reticulum aminopeptidase 2(ERAP2) Homo sapiens This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016], |
| Protein Expression | Plasma,Skeletal muscle,Skin,Trachea, |
| Subcellular Localization | endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,plasma membrane,integral component of membrane, |
| Protein Function | cofactor:Binds 1 zinc ion per subunit.,function:Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.,induction:By IFN-gamma.,miscellaneous:Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M1 family.,subunit:Heterodimer; with ERAP1.,tissue specificity:Ubiquitously expressed. Highly expressed in spleen and leukocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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