ITN2159
ITN2159
ITN2159
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$424.00
Price in reward points: 424
- Catalog: ITN2159
- Gene/Protein: ECE1
- Product Description: Immunotag™ ECE1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein ECE1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000 Concentration 1 mg/ml Reactive Species Human,Rat,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from part region of human protein Specificity ECE1 Polyclonal Antibody detects endogenous levels of protein. Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Gene Name ECE1 Accession No. P42892 Q4PZA2 P42893 Description endothelin converting enzyme 1(ECE1) Homo sapiens The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009], Protein Expression Brain,Epithelium,HUVEC,Liver,Placenta,Platelet,Umbilical vein endothelial c Subcellular Localization lysosomal membrane,endosome,early endosome,plasma membrane,external side of plasma membrane,membrane,integral component of membrane,intrinsic component of endosome membrane,vesicle,Weibel-Palade body,perinuclear region of cytoplasm Protein Function catalytic activity:Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in ECE1 are a cause of Hirschsprung disease, cardiac defects and autonomic dysfunction [MIM:600423]. It is a form of Hirschsprung disease [MIM:142623] with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.,enzyme regulation:Inhibited by phosphoramidon.,function:Converts big endothelin-1 to endothelin-1.,similarity:Belongs to the peptidase M13 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | ECE1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | ECE1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ECE1 |
| Accession No. | P42892 Q4PZA2 P42893 |
| Description | endothelin converting enzyme 1(ECE1) Homo sapiens The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009], |
| Protein Expression | Brain,Epithelium,HUVEC,Liver,Placenta,Platelet,Umbilical vein endothelial c |
| Subcellular Localization | lysosomal membrane,endosome,early endosome,plasma membrane,external side of plasma membrane,membrane,integral component of membrane,intrinsic component of endosome membrane,vesicle,Weibel-Palade body,perinuclear region of cytoplasm |
| Protein Function | catalytic activity:Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in ECE1 are a cause of Hirschsprung disease, cardiac defects and autonomic dysfunction [MIM:600423]. It is a form of Hirschsprung disease [MIM:142623] with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.,enzyme regulation:Inhibited by phosphoramidon.,function:Converts big endothelin-1 to endothelin-1.,similarity:Belongs to the peptidase M13 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |