ITN2167
ITN2167
- Catalog: ITN2167
- Gene/Protein: TICAM2 TIRAP3 TIRP TRAM
- Product Description: Immunotag™ TCAM2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TCAM2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TCAM2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TICAM2 TIRAP3 TIRP TRAM |
| Accession No. | Q86XR7 Q8BJQ4 |
| Description | toll like receptor adaptor molecule 2(TICAM2) Homo sapiens TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004], |
| Cell Pathway/ Category | Toll_Like, |
| Protein Expression | Lung,Placenta,Uterus, |
| Subcellular Localization | early endosome,late endosome,endoplasmic reticulum,Golgi apparatus,plasma membrane,endosome membrane,early endosome membrane,late endosome membrane, |
| Protein Function | domain:The TIR domain mediates the interaction with TRAF6.,function:Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.,PTM:Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.,PTM:Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.,similarity:Belongs to the EMP24/GP25L family.,similarity:Contains 1 GOLD domain.,similarity:Contains 1 TIR domain.,subcellular location:Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.,subunit:Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4.,tissue specificity:Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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