ITN2168
ITN2168
- Catalog: ITN2168
- Gene/Protein: ECE2 KIAA0604 UNQ403/PRO740
- Product Description: Immunotag™ ECE2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ECE2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | ECE2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ECE2 KIAA0604 UNQ403/PRO740 |
| Accession No. | O60344 Q80Z60 |
| Description | endothelin converting enzyme 2(ECE2) Homo sapiens This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013], |
| Protein Expression | Brain,Clones donated by RIKEN,Lung,Ovary,Thalamus, |
| Subcellular Localization | Golgi membrane,integral component of membrane,cytoplasmic vesicle membrane, |
| Protein Function | catalytic activity:Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.,cofactor:Binds 1 zinc ion per subunit.,function:Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.,similarity:In the C-terminal section; belongs to the peptidase M13 family.,similarity:In the N-terminal section; belongs to the methyltransferase superfamily.,tissue specificity:Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disase patients (at protein level)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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