ITN2203
ITN2203
- Catalog: ITN2203
- Gene/Protein: PTPRF LAR
- Product Description: Immunotag™ PTPRF Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PTPRF |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PTPRF Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PTPRF LAR |
| Accession No. | P10586 A2A8L5 Q64604 |
| Description | protein tyrosine phosphatase, receptor type F(PTPRF) Homo sapiens The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pat |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Adherens_Junction,Insulin_Receptor, |
| Protein Expression | Brain,Human cervix,Plasma,Retinoblastoma,Tonsil, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,integral component of membrane,neuron projection,neuronal cell body,extracellular exosome, |
| Protein Function | catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).,function:The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 8 fibronectin type-III domains.,subunit:Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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