ITN2208
ITN2208
- Catalog: ITN2208
- Gene/Protein: FKBP5 AIG6 FKBP51
- Product Description: Immunotag™ FKBP5 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | FKBP5 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | FKBP5 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | FKBP5 AIG6 FKBP51 |
| Accession No. | Q13451 Q64378 |
| Description | FK506 binding protein 5(FKBP5) Homo sapiens The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009], |
| Protein Expression | Aorta endothelial cell,Brain,Epithelium,Liver,Ovary,Testis,Thymus, |
| Subcellular Localization | nucleoplasm,endoplasmic reticulum membrane,membrane,extracellular exosome, |
| Protein Function | catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by FK506 but not cyclosporin.,function:Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.,induction:By androgen.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the FKBP-type PPIase family.,similarity:Contains 2 PPIase FKBP-type domains.,similarity:Contains 3 TPR repeats.,subunit:Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid.,tissue specificity:Widely expressed, enriched in testis compared to other tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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