ITN2212
ITN2212
- Catalog: ITN2212
- Gene/Protein: DPP10 DPRP3 KIAA1492
- Product Description: Immunotag™ DPP10 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | DPP10 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DPP10 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DPP10 DPRP3 KIAA1492 |
| Accession No. | Q8N608 Q6NXK7 Q6Q629 |
| Description | dipeptidyl peptidase like 10(DPP10) Homo sapiens This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Hippocampus,Hypothalamus, |
| Subcellular Localization | plasma membrane,membrane,integral component of membrane, |
| Protein Function | Additional isoforms seem to exist, which may have different subcellular locations,caution:Gly-651 is present instead of the conserved Ser which is expected to be an active site residue.,disease:Defects in DPP10 may be a cause of susceptibility to asthma. Defects in splicing have been observed.,function:Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.,PTM:N-glycosylated.,similarity:Belongs to the peptidase S9B family. DPPIV subfamily.,subunit:May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.,tissue specificity:Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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