ITN2255
ITN2255
- Catalog: ITN2255
- Gene/Protein: STAB2 FEEL2 FELL FEX2 HARE
- Product Description: Immunotag™ STAB2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | STAB2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 980-1060 |
| Specificity | STAB2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | STAB2 FEEL2 FELL FEX2 HARE |
| Accession No. | Q8WWQ8 Q8R4U0 Q8CFM6 |
| Description | stabilin 2(STAB2) Homo sapiens This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008], |
| Protein Expression | Liver,Spleen,Testis, |
| Subcellular Localization | cytoplasm,plasma membrane,integral component of plasma membrane,external side of plasma membrane,endocytic vesicle membrane, |
| Protein Function | domain:Recognizes phosphatidyl serine via its epidermal growth factor-like domains.,function:Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid. May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. Bona fide phosphatidyl serine receptor for cell corpse clearance in macrophages.,PTM:Proteolytically processed to yield a 190 kDa protein.,similarity:Contains 1 Link domain.,similarity:Contains 17 EGF-like domains.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 7 FAS1 domains.,subunit:Interacts with GULP1.,tissue specificity:Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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