ITN2319
ITN2319
- Catalog: ITN2319
- Gene/Protein: SPRY4
- Product Description: Immunotag™ SPY4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SPY4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 230-310 |
| Specificity | SPY4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | SPRY4 |
| Accession No. | Q9C004 Q9WTP2 |
| Description | sprouty RTK signaling antagonist 4(SPRY4) Homo sapiens This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014], |
| Cell Pathway/ Category | Jak_STAT, |
| Protein Expression | Brain,Umbilical artery, |
| Subcellular Localization | cytoplasm,Golgi apparatus,focal adhesion,membrane,ruffle membrane, |
| Protein Function | domain:The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.,function:Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras.,similarity:Belongs to the sprouty family.,similarity:Contains 1 SPR (sprouty) domain.,subunit:Interacts with the C-terminus of TESK1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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