ITN2346
ITN2346
- Catalog: ITN2346
- Gene/Protein: DIABLO SMAC
- Product Description: Immunotag™ DBLOH Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DBLOH |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DBLOH Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DIABLO SMAC |
| Accession No. | Q9NR28 Q9JIQ3 |
| Description | diablo IAP-binding mitochondrial protein(DIABLO) Homo sapiens This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013], |
| Protein Expression | Cerebellum,Chondrosarcoma Lung Metastasis,Muscle,Stomach,Ut |
| Subcellular Localization | mitochondrion,mitochondrial intermembrane space,cytosol,cytoplasmic side of plasma membrane,integral component of membrane,CD40 receptor complex, |
| Protein Function | domain:The mature N-terminus mediates interaction with XIAP.,function:Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).,subcellular location:But released into the cytosol when cells undergo apoptosis.,subunit:Interacts with NGFRAP1/BEX3 (By similarity). Homodimer. Interacts with BIRC2, BIRC3, XIAP and BIRC7.,tissue specificity:Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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