ITN2355
ITN2355
- Catalog: ITN2355
- Gene/Protein: STUB1 CHIP PP1131
- Product Description: Immunotag™ CHIP Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CHIP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 160-240 |
| Specificity | CHIP Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | STUB1 CHIP PP1131 |
| Accession No. | Q9UNE7 Q9WUD1 |
| Description | STIP1 homology and U-box containing protein 1(STUB1) Homo sapiens This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014], |
| Cell Pathway/ Category | Ubiquitin mediated proteolysis, |
| Protein Expression | Colon,Colon carcinoma,Embryonic kidney,Epithelium,Heart,Ski |
| Subcellular Localization | ubiquitin ligase complex,nucleoplasm,cytoplasm,endoplasmic reticulum,cytosol,plasma membrane,Z disc,ubiquitin conjugating enzyme complex,nuclear inclusion body,intermediate filament cytoskeleton,extracellular exosom |
| Protein Function | disease:Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.,function:Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.,PTM:Auto-ubiquitinated (in vitro).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 U-box domain.,similarity:Contains 3 TPR repeats.,subunit:Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.,tissue specificity:Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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