ITN2357
ITN2357
- Catalog: ITN2357
- Gene/Protein: DSC2 CDHF2 DSC3
- Product Description: Immunotag™ DSC2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DSC2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 150-230 |
| Specificity | DSC2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DSC2 CDHF2 DSC3 |
| Accession No. | Q02487 P55292 |
| Description | desmocollin 2(DSC2) Homo sapiens This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015], |
| Cell Pathway/ Category | Arrhythmogenic right ventricular cardiomyopathy (ARVC), |
| Protein Expression | Keratinocyte,Placenta,Plasma,Prostate,Saliva,Salivary gland, |
| Subcellular Localization | plasma membrane,cell-cell adherens junction,intercalated disc,integral component of membrane,desmosome,cytoplasmic vesicle,extracellular exosome, |
| Protein Function | disease:Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia 11 (ARVD11) [MIM:610476]. Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited myocardial disorder associated with ventricular arrhythmias, heart failure, and sudden death. The main pathologic characteristic of ARVD is loss of myocardium, predominately in the right ventricle, and its replacement with adipose and fibrous tissue. Familial ARVD is believed to account for at least 30%-50% of all cases, although penetrance in some families is estimated to be <30%.,domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed in epithelia, myocardium and lymph nodes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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