ITN2380
ITN2380
- Catalog: ITN2380
- Gene/Protein: LGMN PRSC1
- Product Description: Immunotag™ LGMN Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | LGMN |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 60-140 |
| Specificity | LGMN Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | LGMN PRSC1 |
| Accession No. | Q99538 O89017 Q9R0J8 |
| Description | legumain(LGMN) Homo sapiens This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Lysosome,Antigen processing and presentation, |
| Protein Expression | Heart,Liver,Neuroblastoma,Ovary,Placenta, |
| Subcellular Localization | lysosome,late endosome,lysosomal lumen,apical part of cell,extracellular exosome, |
| Protein Function | catalytic activity:Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.,function:Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.,PTM:Glycosylated.,similarity:Belongs to the peptidase C13 family.,tissue specificity:Ubiquitous. Particularly abundant in kidney, heart and placenta., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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