ITN2407
ITN2407
- Catalog: ITN2407
- Gene/Protein: IBSP BNSP
- Product Description: Immunotag™ SIAL Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SIAL |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 230-310 |
| Specificity | SIAL Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | IBSP BNSP |
| Accession No. | P21815 Q61711 P13839 |
| Description | integrin binding sialoprotein(IBSP) Homo sapiens The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Focal adhesion,ECM-receptor interaction, |
| Subcellular Localization | extracellular region,extracellular space,membrane,extracellular matrix,vesicle,membrane-bounded vesicle, |
| Protein Function | function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.,miscellaneous:It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.,PTM:N-glycosylated; glycans consist of sialated and core-fucosylated bi-, tri- and tetraantennary chains.,PTM:O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.,PTM:Sulfated on either Tyr-313 or Tyr-314., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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