ITN2414
ITN2414
- Catalog: ITN2414
- Gene/Protein: FCGR3B CD16B FCG3 FCGR3 IGFR3
- Product Description: Immunotag™ FCG3B Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | FCG3B |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 90-170 |
| Specificity | FCG3B Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | FCGR3B CD16B FCG3 FCGR3 IGFR3 |
| Accession No. | O75015 |
| Description | Fc fragment of IgG receptor IIIb(FCGR3B) Homo sapiens The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012], |
| Cell Pathway/ Category | Natural killer cell mediated cytotoxicity,Systemic lupus erythematosus, |
| Protein Expression | Leukocyte,Peripheral blood,Placenta, |
| Subcellular Localization | plasma membrane,integral component of membrane,anchored component of membrane,extracellular exosome, |
| Protein Function | disease:The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.,function:Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.,miscellaneous:Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The Phe-203 in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.,polymorphism:There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA.,PTM:Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.,PTM:The soluble form is produced by a proteolytic cleavage.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Secreted after cleavage.,subunit:Monomer. Interacts with INPP5D/SHIP1.,tissue specificity:Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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