ITN2440
ITN2440
- Catalog: ITN2440
- Gene/Protein: NRG4
- Product Description: Immunotag™ NRG4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NRG4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 11-60 |
| Specificity | NRG4 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NRG4 |
| Accession No. | Q8WWG1 Q9WTX4 |
| Description | neuregulin 4(NRG4) Homo sapiens The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008], |
| Cell Pathway/ Category | ErbB_HER, |
| Protein Expression | Breast,Liver,Prostate, |
| Subcellular Localization | extracellular region,extracellular space,intracellular,plasma membrane,integral component of membrane, |
| Protein Function | domain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.,PTM:Extensive glycosylation precedes the proteolytic cleavage.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,subcellular location:Does not seem to be active., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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