ITN2486
ITN2486
- Catalog: ITN2486
- Gene/Protein: ZFYVE26 KIAA0321
- Product Description: Immunotag™ ZFY26 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ZFY26 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 2381-2430 |
| Specificity | ZFY26 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | ZFYVE26 KIAA0321 |
| Accession No. | Q68DK2 Q5DU37 D4A8G9 |
| Description | zinc finger FYVE-type containing 26(ZFYVE26) Homo sapiens This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008], |
| Protein Expression | Brain,Cervix,Endometrial adenocarcinoma,Epithelium,Fetal kidney,Ova |
| Subcellular Localization | lysosomal membrane,centrosome,midbody, |
| Protein Function | disease:Defects in ZFYVE26 are the cause of spastic paraplegia autosomal recessive type 15 (SPG15) [MIM:270700]; also known as spastic paraplegia and retinal degeneration or Kjellin syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration.,sequence caution:Translated as Gln.,similarity:Contains 1 FYVE-type zinc finger.,tissue specificity:Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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