ITN2563
ITN2563
- Catalog: ITN2563
- Gene/Protein: NPSR1 GPR154 GPRA PGR14
- Product Description: Immunotag™ NPSR1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NPSR1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | NPSR1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | NPSR1 GPR154 GPRA PGR14 |
| Accession No. | Q6W5P4 Q8BZP8 P0C0L6 |
| Description | neuropeptide S receptor 1(NPSR1) Homo sapiens This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], |
| Subcellular Localization | cytoplasm,plasma membrane,integral component of plasma membrane,integral component of membrane, |
| Protein Function | disease:NPSR1 is associated with susceptibility to asthma and elevated serum IgE levels [MIM:608584]. Polymorphisms may influence the development of asthma and bronchial hyperresponsiveness in adult, and are significantly associated with allergic sensitization and rhinoconjunctivis, as well as asthma in children.,function:May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases.,miscellaneous:Only isoforms with 7 transmembrane topology (isoform 1, isoform 3 and isoform 4) are transported into the plasma membrane in transfected cells, while the truncated ones retain intracellular compartments.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle, and isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, isoform 4 is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, isoform 4 expression is consistently stronger in asthma patients., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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