ITN2679
ITN2679
- Catalog: ITN2679
- Gene/Protein: P2RY12 HORK3
- Product Description: Immunotag™ P2Y12 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | P2Y12 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein, at AA range: 110-190 |
| Specificity | P2Y12 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | P2RY12 HORK3 |
| Accession No. | Q9H244 Q9CPV9 Q9EPX4 |
| Description | purinergic receptor P2Y12(P2RY12) Homo sapiens The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013], |
| Protein Expression | Blood,Brain,Hypothalamus,Prostate, |
| Subcellular Localization | mitochondrion,plasma membrane,integral component of plasma membrane,caveola,external side of plasma membrane,basal plasma membrane,cell surface,integral component of membrane,intrinsic component of membrane, |
| Protein Function | disease:Defects in P2RY12 are a cause of bleeding disorder [MIM:609821].,function:Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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