ITN2846
ITN2846
- Catalog: ITN2846
- Gene/Protein: SCN8A MED
- Product Description: Immunotag™ SCN8A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SCN8A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SCN8A Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | SCN8A MED |
| Accession No. | Q9UQD0 Q9WTU3 O88420 |
| Description | sodium voltage-gated channel alpha subunit 8(SCN8A) Homo sapiens This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
| Protein Expression | Brain,Dorsal root ganglia,Fetal brain, |
| Subcellular Localization | voltage-gated sodium channel complex,plasma membrane,integral component of membrane,cytoplasmic, membrane-bounded vesicle,Z disc,cytoplasmic vesicle,node of Ranvier,axon initial segment, |
| Protein Function | domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,function:Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.,PTM:May be ubiquitinated by NEDD4L; which would promote its endocytosis.,similarity:Belongs to the sodium channel family.,similarity:Contains 1 IQ domain.,subunit:Interacts with NEDD4 and NEDD4L., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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