ITN2862
ITN2862
- Catalog: ITN2862
- Gene/Protein: TNFRSF18 AITR GITR UNQ319/PRO364
- Product Description: Immunotag™ TNR18 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TNR18 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TNR18 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | TNFRSF18 AITR GITR UNQ319/PRO364 |
| Accession No. | Q9Y5U5 O35714 |
| Description | TNF receptor superfamily member 18(TNFRSF18) Homo sapiens This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction, |
| Protein Expression | Bone marrow,Clones donated by HIP,T-cell,Thymus, |
| Subcellular Localization | extracellular region,plasma membrane,integral component of plasma membrane, |
| Protein Function | function:Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.,induction:Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.,tissue specificity:Expressed in lymph node, peripheral blood leukocytes and weakly in spleen., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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