ITN2890
ITN2890
- Catalog: ITN2890
- Gene/Protein: DVL1
- Product Description: Immunotag™ DVL1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DVL1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DVL1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DVL1 |
| Accession No. | O14640 P51141 Q9WVB9 |
| Description | dishevelled segment polarity protein 1(DVL1) Homo sapiens DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | WNT,WNT-T CELLNotch,Melanogenesis,Pathways in cancer,Colorectal cancer,Basal cell carcinoma, |
| Protein Expression | Brain,Eye,Peripheral Nervous System,Sympathetic ganglion,Testis, |
| Subcellular Localization | intracellular,cytosol,microtubule,plasma membrane,postsynaptic density,cytoplasmic, membrane-bounded vesicle,lateral plasma membrane,clathrin-coated vesicle,axon,growth cone,cytoplasmic vesicle,neuron projection, |
| Protein Function | disease:May be partly responsible for CATCH22 syndromes. This denomination includes developmental defects which associate cardiac defect, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, and chromosome 22 deletions.,function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE.,tissue specificity:Expressed in the thymus and, at high levels, in the heart., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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