ITN2927
ITN2927
- Catalog: ITN2927
- Gene/Protein: DIAPH2 DIA
- Product Description: Immunotag™ DIAP2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DIAP2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DIAP2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DIAPH2 DIA |
| Accession No. | O60879 O70566 |
| Description | diaphanous related formin 2(DIAPH2) Homo sapiens The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Regulates Actin and Cytoskeleton, |
| Protein Expression | Brain,Epithelium, |
| Subcellular Localization | nucleolus,mitochondrion,early endosome,Golgi apparatus,cytosol,intracellular membrane-bounded organelle, |
| Protein Function | developmental stage:Expressed from E16 in ovary and testis and during P6-P16 during differentiation of ovarian follicles.,disease:Defects in DIAPH2 are a cause of premature ovarian failure 2 (POF2) [MIM:300511]. Premature ovarian failure (POF) is a defect of ovarian development and is characterized by hypoestrogenism, primary or secondary amenorrhea, with elevated levels of serum gonadotropins, or by early menopause. POF is defined as the cessation of ovarian function under the age of 40 years. The disorder has been attributed to various causes, including rearrangements of a large "critical region" in the long arm of the X chromosome.,domain:DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction.,function:Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.,similarity:Belongs to the formin homology family. Diaphanous subfamily.,similarity:Contains 1 DAD (diaphanous autoregulatory) domain.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,similarity:Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.,subcellular location:Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.,subunit:Isoform 3 interacts with RHOD in the GTP-bound form.,tissue specificity:Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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