ITN2935
ITN2935
- Catalog: ITN2935
- Gene/Protein: MTPN
- Product Description: Immunotag™ MTPN Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MTPN |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | MTPN Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | MTPN |
| Accession No. | P58546 P62774 P62775 |
| Description | myotrophin(MTPN) Homo sapiens The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008], |
| Protein Expression | Amygdala,Lung,Testis, |
| Subcellular Localization | nucleus,cytosol,F-actin capping protein complex,axon,perinuclear region of cytoplasm,extracellular exosome, |
| Protein Function | function:Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy.,induction:By IFNA1.,miscellaneous:Elicits IgG antibody response in a subset of polycythemia vera patients and as well in patients with chronic myelogenous leukemia and prostate cancer receiving IFNA1 or other therapy, suggesting that it is broadly immunogenic.,miscellaneous:This protein is produced by a bicistronic gene which also produces the MPD6 protein from a non-overlapping reading frame. MPD6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.,miscellaneous:This protein is produced by a bicistronic gene which also produces the MTPN protein from a non-overlapping reading frame. LUZP6 belongs to a group of cryptic antigens without conventional genomic structure. It is encoded by a cryptic open reading frame located in the 3'-untranslated region of MTPN.,similarity:Belongs to the myotrophin family.,similarity:Contains 3 ANK repeats.,tissue specificity:Ubiquitous.,tissue specificity:Widely expressed, highest levels found in brain, placenta, spleen, testis, and ovary. Up-regulated in some tumor cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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