ITN2957
ITN2957
- Catalog: ITN2957
- Gene/Protein: GSS
- Product Description: Immunotag™ GSHB Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | GSHB |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | GSHB Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | GSS |
Accession No. | P48637 P51855 P46413 |
Description | glutathione synthetase(GSS) Homo sapiens Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | Glutathione metabolism, |
Protein Expression | Brain,Fetal brain cortex,Kidney,Lung, |
Subcellular Localization | cytosol,extracellular exosome, |
Protein Function | catalytic activity:ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.,disease:Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency) [MIM:266130]; referred to as 5-oxoprolinuria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.,disease:Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes [MIM:231900]. It is a mild form causing hemolytic anemia.,pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.,similarity:Belongs to the eukaryotic GSH synthase family.,subunit:Homodimer., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |