ITN2961
ITN2961
- Catalog: ITN2961
- Gene/Protein: HLA-E HLA-6.2 HLAE
- Product Description: Immunotag™ HLAE Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HLAE |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | HLAE Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | HLA-E HLA-6.2 HLAE |
| Accession No. | P13747 |
| Description | major histocompatibility complex, class I, E(HLA-E) Homo sapiens HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Endocytosis,Cell adhesion molecules (CAMs),Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Type I diabetes mellitus,Autoimmune thyroid disease,Allograft rejection,Graft-versus-host disease,Viral myocarditis, |
| Protein Expression | Aorta endothelial cell,Blood,Human rectum tumor,Lung,Ovaria |
| Subcellular Localization | Golgi membrane,plasma membrane,cell surface,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,phagocytic vesicle membrane,early endosome membrane,MHC class Ib protein complex,MHC class I protein co |
| Protein Function | caution:The existence of allele E*0102 (PubMed:3260916) and allele E*0104 (PubMed:1977695) is uncertain. The alleles could not be confirmed in further studies (PubMed:12445303).,function:Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.,polymorphism:The following alleles of E-1 are known: E*0101, E*0102, E*0103 and E*0104. The sequence shown is that of E*0101.,similarity:Belongs to the MHC class I family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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