ITP0268
ITP0268
- Catalog: ITP0268
- Gene/Protein: TENC1
- Product Description: Immunotag™ Tensin-2 (phospho Tyr483) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Tensin-2 (Tyr483) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Tensin-2 (phospho Tyr483) |
| Specificity | Phospho-Tensin-2 (Y483) Polyclonal Antibody detects endogenous levels of Tensin-2 protein only when phosphorylated at Y483. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TENC1 |
| Accession No. | Q63HR2 Q8CGB6 |
| Alternate Names | TENC1; KIAA1075; TNS2; Tensin-like C1 domain-containing phosphatase; C1 domain-containing phosphatase and tensin homolog; C1-TEN; Tensin-2 |
| Description | tensin 2(TNS2) Homo sapiens The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008], |
| Protein Expression | Adipose tissue,Brain,Colon endothelium,Epithelium,Kidney,Testis,Uterus, |
| Subcellular Localization | intracellular,plasma membrane,focal adhesion, |
| Protein Function | function:Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subcellular location:Detected at the end of actin stress fibers.,subunit:Interacts with AXL.,tissue specificity:Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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