ITP0379
ITP0379
- Catalog: ITP0379
- Gene/Protein: CD40
- Product Description: Immunotag™ CD40 (phospho Thr254) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD40 (Thr254) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFRSF5 around the phosphorylation site of Thr254. AA range:220-269 |
| Specificity | Phospho-CD40 (T254) Polyclonal Antibody detects endogenous levels of CD40 protein only when phosphorylated at T254. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CD40 |
| Accession No. | P25942 P27512 |
| Alternate Names | CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40 |
| Description | CD40 molecule(CD40) Homo sapiens This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Cell adhesion molecules (CAMs),Toll_Like,Intestinal immune network for IgA production,Asthma,Autoimmune thyroid disease,Systemic lupus erythematosus,Allograft rejection,Primary immunodeficiency,Viral myocarditis, |
| Protein Expression | Kidney,Leukocyte,Lymphoma,Ovary,Pancreas,Spleen,Urinary bladder carcinoma, |
| Subcellular Localization | extracellular space,cytoplasm,plasma membrane,integral component of plasma membrane,external side of plasma membrane,cell surface,integral component of membrane,CD40 receptor complex,intracellular membrane-bounded organelle,extracellular exosome, |
| Protein Function | Additional isoforms seem to exist,disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.,function:Receptor for TNFSF5/CD40LG.,online information:CD40 entry,online information:CD40 mutation db,similarity:Contains 4 TNFR-Cys repeats.,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:B-cells and in primary carcinomas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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