ITP0454
ITP0454
- Catalog: ITP0454
- Gene/Protein: CAV2
- Product Description: Immunotag™ Caveolin-2 (phospho Tyr27) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Caveolin-2 (Tyr27) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caveolin 2 around the phosphorylation site of Tyr27. AA range:12-61 |
| Specificity | Phospho-Caveolin-2 (Y27) Polyclonal Antibody detects endogenous levels of Caveolin-2 protein only when phosphorylated at Y27. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CAV2 |
| Accession No. | P51636 Q9WVC3 |
| Alternate Names | CAV2; Caveolin-2 |
| Description | caveolin 2(CAV2) Homo sapiens The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011], |
| Cell Pathway/ Category | Focal adhesion, |
| Protein Expression | Epithelium,Kidney,Thalamus, |
| Subcellular Localization | Golgi membrane,acrosomal membrane,intracellular,nucleus,Golgi apparatus,plasma membrane,integral component of plasma membrane,caveola,focal adhesion,membrane,integral component of membrane,transport vesicle,extrinsic componen |
| Protein Function | function:May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.,function:May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1.,online information:Caveolin entry,similarity:Belongs to the caveolin family.,subcellular location:Potential hairpin-like structure in the membrane. Membrane protein of caveolae.,subunit:Homodimer. Caveolin-1 and -2 colocalize and form a stable hetero-oligomeric complex.,tissue specificity:Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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