Datasheet |
|
Target Protein |
BAM32 (Tyr139) |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
WB,IHC-p,IF,ELISA |
Recommended Dilution |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
Concentration |
1 mg/ml |
Reactive Species |
Human,Mouse |
Host Species |
Rabbit |
Immunogen |
The antiserum was produced against synthesized peptide derived from human DAPP1 around the phosphorylation site of Tyr139. AA range:105-154 |
Specificity |
Phospho-BAM32 (Y139) Polyclonal Antibody detects endogenous levels of BAM32 protein only when phosphorylated at Y139. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name |
DAPP1 |
Accession No. |
Q9UN19 Q9QXT1 |
Alternate Names |
DAPP1; BAM32; HSPC066; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; hDAPP1; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa |
Description |
function:May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.,induction:Upon B-cell activation.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH2 domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation.,subunit:Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2.,tissue specificity:Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells., |
Cell Pathway/ Category |
B_Cell_Antigen, |
Protein Expression |
Lymph node,Umbilical cord blood,Urinary bla |
Subcellular Localization |
cytosol,plasma membrane, |
Protein Function |
function:May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.,induction:Upon B-cell activation.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH2 domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation.,subunit:Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2.,tissue specificity:Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |