ITP1005
ITP1005
- Catalog: ITP1005
- Gene/Protein: KCND2
- Product Description: Immunotag™ Kv4.2 (phospho Ser616) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | KV4.2 (Ser616) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Kv42 (phospho Ser616) |
| Specificity | Phospho-Kv4.2 (S616) Polyclonal Antibody detects endogenous levels of Kv4.2 protein only when phosphorylated at S616. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | KCND2 |
| Accession No. | Q9NZV8 Q9Z0V2 Q63881 |
| Alternate Names | KCND2; KIAA1044; Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel subunit Kv4.2 |
| Description | potassium voltage-gated channel subfamily D member 2(KCND2) Homo sapiens Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as i |
| Protein Expression | Brain,Brain cortex, |
| Subcellular Localization | plasma membrane,integral component of plasma membrane,voltage-gated potassium channel complex,cell junction,intrinsic component of plasma membrane,neuronal cell body membrane,neuronal cell body,dendritic spine,perikaryon, |
| Protein Function | domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the potassium channel family. D (Shal) subfamily.,subcellular location:Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.,subunit:Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and FREQ (By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10.,tissue specificity:Highly expressed throughout the brain. Expression is very low or absent in other tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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