ITP1042
ITP1042
- Catalog: ITP1042
- Gene/Protein: EIF2AK4
- Product Description: Immunotag™ GCN2 (phospho Thr899) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GCN2 (Thr899) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GCN2 around the phosphorylation site of Thr899. AA range:865-914 |
| Specificity | Phospho-GCN2 (T899) Polyclonal Antibody detects endogenous levels of GCN2 protein only when phosphorylated at T899. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | EIF2AK4 |
| Accession No. | Q9P2K8 Q9QZ05 |
| Alternate Names | EIF2AK4; GCN2; KIAA1338; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein |
| Description | eukaryotic translation initiation factor 2 alpha kinase 4(EIF2AK4) Homo sapiens This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014], |
| Protein Expression | Brain,Epithelium,Melanoma,Muscle,Testis,Ute |
| Subcellular Localization | polysome,cytosolic ribosome, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:Kinase domain 1 is a degenerate kinase domain.,domain:RWD domain is reported to interact with GCN1L1.,function:Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.,PTM:Autophosphorylated on threonine residues.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 RWD domain.,similarity:Contains 2 protein kinase domains.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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