Datasheet |
|
Target Protein |
CNOT2 (Ser101) |
Clonality |
Polyclonal |
Storage/Stability |
-20°C/1 year |
Application |
IHC-p,ELISA |
Recommended Dilution |
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
Concentration |
1 mg/ml |
Reactive Species |
Human,Mouse,Rat |
Host Species |
Rabbit |
Immunogen |
The antiserum was produced against synthesized peptide derived from human CNOT2 around the phosphorylation site of Ser101. AA range:67-116 |
Specificity |
Phospho-CNOT2 (S101) Polyclonal Antibody detects endogenous levels of CNOT2 protein only when phosphorylated at S101. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name |
CNOT2 |
Accession No. |
Q9NZN8 Q8C5L3 |
Alternate Names |
CNOT2; CDC36; NOT2; HSPC131; MSTP046; CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2 |
Description |
CCR4-NOT transcription complex subunit 2(CNOT2) Homo sapiens This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010], |
Cell Pathway/ Category |
RNA degradation, |
Protein Expression |
Fetal kidney,Heart,Kidney,Lymph,Skin,Testis,Thyroid,Umbilical cord |
Subcellular Localization |
cytoplasmic mRNA processing body,nucleus,cytoplasm,cytosol,membrane,CCR4-NOT complex,CCR4-NOT core complex, |
Protein Function |
function:The CCR4-NOT complex functions as general transcription regulation complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CNOT2/3/5 family.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8.,tissue specificity:Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes., |
Usage |
For Research Use Only! Not for diagnostic or therapeutic procedures. |