ITP1187
ITP1187
- Catalog: ITP1187
- Gene/Protein: HRH1
- Product Description: Immunotag™ Histamine H1 Receptor (phospho Ser398) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Histamine H1 Receptor |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IF,ELISA |
| Recommended Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Histamine H1 Receptor (phospho Ser398) |
| Specificity | Phospho-Histamine H1 Receptor (S398) Polyclonal Antibody detects endogenous levels of Histamine H1 Receptor protein only when phosphorylated at S398. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HRH1 |
| Accession No. | P35367 P70174 P31390 |
| Alternate Names | HRH1; Histamine H1 receptor; H1R; HH1R |
| Description | histamine receptor H1(HRH1) Homo sapiens Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by Ref |
| Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction, |
| Protein Expression | Lens epithelium,Lung, |
| Subcellular Localization | nucleoplasm,cytoplasm,plasma membrane,integral component of plasma membrane, |
| Protein Function | function:In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.,PTM:Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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