ITT0029
ITT0029
- Catalog: ITT0029
- Gene/Protein: ADCY1
- Product Description: Immunotag™ A Cyclase I Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | A Cyclase I |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADCY1. AA range:231-280 |
| Specificity | A Cyclase I Polyclonal Antibody detects endogenous levels of A Cyclase I protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ADCY1 |
| Accession No. | Q08828 O88444 |
| Alternate Names | ADCY1; Adenylate cyclase type 1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase |
| Description | adenylate cyclase 1(ADCY1) Homo sapiens This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013], |
| Cell Pathway/ Category | Purine metabolism,Calcium,Chemokine,Oocyte meiosis,Vascular smooth muscle contraction,Gap junction,Long-term potentiation,GnRH,Progesterone-mediated oocyte maturation,Melanogenesis,Dilated cardiomyopathy, |
| Protein Expression | Brain,Fetal brain, |
| Subcellular Localization | intracellular,nucleus,cytoplasm,plasma membrane,integral component of plasma membrane,integral component of membrane,membrane raft,extracellular exosome, |
| Protein Function | catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.,function:This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Brain, retina and adrenal medulla., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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