ITT0037
ITT0037
- Catalog: ITT0037
- Gene/Protein: TNFAIP3
- Product Description: Immunotag™ A20 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | A20 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNAP3. AA range:321-370 |
| Specificity | A20 Polyclonal Antibody detects endogenous levels of A20 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TNFAIP3 |
| Accession No. | P21580 Q60769 |
| Alternate Names | TNFAIP3; OTUD7C; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20 |
| Description | TNF alpha induced protein 3(TNFAIP3) Homo sapiens This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012], |
| Cell Pathway/ Category | NOD-like receptor, |
| Protein Expression | Epithelium,Testis,Trachea, |
| Subcellular Localization | nucleus,cytoplasm,lysosome,cytosol,extracellular exosome, |
| Protein Function | function:Interacts with NAF1 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system and may contribute to the in vivo effects of TNF (By similarity). Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains.,induction:By TNF-alpha.,similarity:Belongs to the peptidase C64 family.,similarity:Contains 1 OTU domain.,similarity:Contains 7 A20-type zinc fingers.,subunit:Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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