ITT0107
ITT0107
- Catalog: ITT0107
- Gene/Protein: ACVR1C
- Product Description: Immunotag™ ACTR-IC Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ACTR-IC |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from ACTR-IC, at AA range: 180-260 |
| Specificity | ACTR-IC Polyclonal Antibody detects endogenous levels of ACTR-IC protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ACVR1C |
| Accession No. | Q8NER5 Q8K348 P70539 |
| Alternate Names | ACVR1C; ALK7; Activin receptor type-1C; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7 |
| Description | activin A receptor type 1C(ACVR1C) Homo sapiens ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Endocytosis,TGF-beta,Adherens_Junction,Pathways in cancer,Colorectal cancer,Pancreatic cancer,Chronic myeloid leukemia, |
| Protein Expression | Brain,Placenta, |
| Subcellular Localization | plasma membrane,activin receptor complex, |
| Protein Function | catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds the type 2 receptor protein ACVR2A.,tissue specificity:Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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