ITT0114
ITT0114
- Catalog: ITT0114
- Gene/Protein: ADAMTS16
- Product Description: Immunotag™ ADAMTS-16 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ADAMTS-16 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from ADAMTS-16 . at AA range: 440-520 |
| Specificity | ADAMTS-16 Polyclonal Antibody detects endogenous levels of ADAMTS-16 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ADAMTS16 |
| Accession No. | Q8TE57 Q69Z28 |
| Alternate Names | ADAMTS16; KIAA2029; A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM-TS 16; ADAM-TS16; ADAMTS-16 |
| Description | ADAM metallopeptidase with thrombospondin type 1 motif 16(ADAMTS16) Homo sapiens This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016], |
| Protein Expression | Brain,Epithelium, |
| Subcellular Localization | proteinaceous extracellular matrix, |
| Protein Function | cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 6 TSP type-1 domains.,tissue specificity:Expressed in fetal lung and kidney and in adult prostate and ovary., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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