ITT0130
ITT0130
- Catalog: ITT0130
- Gene/Protein: ADORA2A
- Product Description: Immunotag™ Adenosine A2A-R Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Adenosine A2A-R |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADORA2A. AA range:321-370 |
| Specificity | Adenosine A2A-R Polyclonal Antibody detects endogenous levels of Adenosine A2A-R protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ADORA2A |
| Accession No. | P29274 Q60613 |
| Alternate Names | ADORA2A; ADORA2; Adenosine receptor A2a |
| Description | adenosine A2a receptor(ADORA2A) Homo sapiens This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript compos |
| Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction,Vascular smooth muscle contraction, |
| Protein Expression | Brain,Hippocampus,Lymph,Thymus, |
| Subcellular Localization | intermediate filament,plasma membrane,integral component of plasma membrane,endomembrane system,postsynaptic density,membrane,integral component of membrane,dendrite,axolemma,asymmetric synapse,presynaptic membrane,neuronal cell |
| Protein Function | function:Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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