ITT0211
ITT0211
- Catalog: ITT0211
- Gene/Protein: AMPD1
- Product Description: Immunotag™ AMPD1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | AMPD1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from AMPD1, at AA range: 230-310 |
| Specificity | AMPD1 Polyclonal Antibody detects endogenous levels of AMPD1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | AMPD1 |
| Accession No. | P23109 Q3V1D3 P10759 |
| Alternate Names | AMPD1; AMP deaminase 1; AMP deaminase isoform M; Myoadenylate deaminase |
| Description | adenosine monophosphate deaminase 1(AMPD1) Homo sapiens Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010], |
| Cell Pathway/ Category | Purine metabolism, |
| Protein Expression | Skeletal muscle, |
| Subcellular Localization | cytosol, |
| Protein Function | catalytic activity:AMP + H(2)O = IMP + NH(3).,disease:Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM) [MIM:102770]. AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue.,function:AMP deaminase plays a critical role in energy metabolism.,pathway:Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.,similarity:Belongs to the adenosine and AMP deaminases family.,subunit:Homotetramer.,tissue specificity:Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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