ITT0270
ITT0270
- Catalog: ITT0270
- Gene/Protein: APOBEC3A
- Product Description: Immunotag™ APOBEC3A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | APOBEC3A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human APOBEC3A. AA range:27-76 |
| Specificity | APOBEC3A Polyclonal Antibody detects endogenous levels of APOBEC3A protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | APOBEC3A |
| Accession No. | P31941 |
| Alternate Names | APOBEC3A; Probable DNA dC->dU-editing enzyme APOBEC-3A; Phorbolin-1 |
| Description | apolipoprotein B mRNA editing enzyme catalytic subunit 3A(APOBEC3A) Homo sapiens This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided b |
| Protein Expression | Brain,Keratinocyte, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm, |
| Protein Function | cofactor:Zinc.,function:Lacks cytidine deaminase activity, at least on RNA molecules (monomeric nucleoside substrates or synthetic apoB RNA template). Unable to reduce HIV-1 infectivity in vitro.,miscellaneous:It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,tissue specificity:Expressed in peripherical leukocytes and keratinocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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