ITT0321
ITT0321
- Catalog: ITT0321
- Gene/Protein: ARHGEF10
- Product Description: Immunotag™ ARHGEF10 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ARHGEF10 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Monkey |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388 |
| Specificity | ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ARHGEF10 |
| Accession No. | O15013 Q8C033 |
| Alternate Names | ARHGEF10; KIAA0294; Rho guanine nucleotide exchange factor 10 |
| Description | Rho guanine nucleotide exchange factor 10(ARHGEF10) Homo sapiens This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015], |
| Cell Pathway/ Category | Regulation of Actin Dynamics, AMPK |
| Protein Expression | Amygdala,Brain,Duodenum,Prostate,Testis,Uterus, |
| Subcellular Localization | centrosome,cytosol, |
| Protein Function | disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,function:May play a role in developmental myelination of peripheral nerves.,sequence caution:Cloning artifact.,sequence caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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