ITT0359
ITT0359
- Catalog: ITT0359
- Gene/Protein: ADRB1
- Product Description: Immunotag™ AR-β1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | AR-β1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from AR-β1, at AA range: 250-330 |
| Specificity | AR-β1 Polyclonal Antibody detects endogenous levels of AR-β1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ADRB1 |
| Accession No. | P08588 P34971 P18090 |
| Alternate Names | ADRB1; ADRB1R; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor |
| Description | adrenoceptor beta 1(ADRB1) Homo sapiens The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction,Endocytosis,Gap junction,Dilated cardiomyopathy, |
| Protein Expression | Placenta, |
| Subcellular Localization | early endosome,plasma membrane,integral component of plasma membrane, |
| Protein Function | domain:The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.,PTM:Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.,subunit:Interacts with GOPC, MAGI3 and DLG4., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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