ITT0377
ITT0377
- Catalog: ITT0377
- Gene/Protein: ZFHX3
- Product Description: Immunotag™ ATBF1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ATBF1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ZFHX3. AA range:761-810 |
| Specificity | ATBF1 Polyclonal Antibody detects endogenous levels of ATBF1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ZFHX3 |
| Accession No. | Q15911 Q61329 |
| Alternate Names | ZFHX3; ATBF1; Zinc finger homeobox protein 3; AT motif-binding factor; AT-binding transcription factor 1; Alpha-fetoprotein enhancer-binding protein; Zinc finger homeodomain protein 3; ZFH-3 |
| Description | zinc finger homeobox 3(ZFHX3) Homo sapiens This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009], |
| Protein Expression | Cervix,Epithelium,Hepatoma,Lung,Platelet, |
| Subcellular Localization | nucleus,nucleoplasm,transcription factor complex,nucleolus,cytoplasm,nuclear body,intracellular membrane-bounded organelle, |
| Protein Function | function:Transcriptional activator that binds to the AT-rich core sequence of the enhancer element of the AFP gene.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 22 C2H2-type zinc fingers.,similarity:Contains 4 homeobox DNA-binding domains.,subunit:Interacts with FNBP3., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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