ITT0498
ITT0498
- Catalog: ITT0498
- Gene/Protein: BMP2
- Product Description: Immunotag™ BMP-2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | BMP-2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human BMP-2 |
| Specificity | BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | BMP2 |
| Accession No. | P12643 P21274 P49001 |
| Alternate Names | BMP2; BMP2A; Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A |
| Description | bone morphogenetic protein 2(BMP2) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Hedgehog,TGF-beta,Pathways in cancer,Basal cell carcinoma, |
| Subcellular Localization | extracellular region,extracellular space,cell surface,BMP receptor complex, |
| Protein Function | function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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