ITT0513
ITT0513
- Catalog: ITT0513
- Gene/Protein: BNIP3
- Product Description: Immunotag™ BNIP-3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | BNIP-3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BNIP-3. AA range:47-96 |
| Specificity | BNIP-3 Polyclonal Antibody detects endogenous levels of BNIP-3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | BNIP3 |
| Accession No. | Q12983 O55003 |
| Alternate Names | BNIP3; NIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| Description | BCL2 interacting protein 3(BNIP3) Homo sapiens This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014], |
| Protein Expression | B-cell,Brain,Cerebellum,Kidney,Testis, |
| Subcellular Localization | nucleus,nuclear envelope,nucleoplasm,cytoplasm,mitochondrion,mitochondrial envelope,mitochondrial outer membrane,endoplasmic reticulum,postsynaptic density,integral component of membrane,dendrite,integral component of mi |
| Protein Function | function:Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.,similarity:Belongs to the NIP3 family.,subcellular location:Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope.,subunit:Homodimer. Binds to BCL2. Interacts with BNIP3L. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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