ITT0538
ITT0538
- Catalog: ITT0538
- Gene/Protein: BST1
- Product Description: Immunotag™ BST-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | BST-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Monkey |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from BST-1, at AA range: 40-120 |
| Specificity | BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | BST1 |
| Accession No. | Q10588 Q64277 Q63072 |
| Alternate Names | BST1; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2; CD antigen CD157 |
| Description | bone marrow stromal cell antigen 1(BST1) Homo sapiens Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Nicotinate and nicotinamide metabolism,Calcium, |
| Protein Expression | Liver,Lung,Plasma, |
| Subcellular Localization | plasma membrane,extrinsic component of membrane,anchored component of membrane,extracellular exosome, |
| Protein Function | catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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