ITT0599
ITT0599
- Catalog: ITT0599
- Gene/Protein: CDH23
- Product Description: Immunotag™ Cadherin-23 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Cadherin-23 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IF,ELISA |
| Recommended Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Cadherin-23, at AA range: 30-110 |
| Specificity | Cadherin-23 Polyclonal Antibody detects endogenous levels of Cadherin-23 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CDH23 |
| Accession No. | Q9H251 Q99PF4 P58365 |
| Alternate Names | CDH23; KIAA1774; KIAA1812; Cadherin-23; Otocadherin |
| Description | cadherin related 23(CDH23) Homo sapiens This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013], |
| Cell Pathway/ Category | Adherens_Junction |
| Protein Expression | Brain,Donated clones,Eye,Retina,Spleen,Testis,Thymus, |
| Subcellular Localization | plasma membrane,membrane,integral component of membrane,stereocilium, |
| Protein Function | Additional isoforms seem to exist,disease:Defects in CDH23 are a cause of Usher syndrome type 1D/F (USH1DF) [MIM:601067]. USH1DF patients are heterozygous for mutations in CDH23 and PCDH15, indicating a digenic inheritance pattern.,disease:Defects in CDH23 are the cause of non-syndromic sensorineural deafness autosomal recessive type 12 (DFNB12) [MIM:601386]. DFNB12 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,disease:Defects in CDH23 are the cause of Usher syndrome type 1D (USH1D) [MIM:601067]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development.,online information:Retina International's Scientific Newsletter,similarity:Contains 27 cadherin domains.,tissue specificity:Particularly strong expression in the retina. Found also in the cochlea., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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